| Title : Bioactive clerodane diterpenes of giant goldenrod (Solidago gigantea Ait.) root extract - Moricz_2021_J.Chromatogr.A_1635_461727 |
| Author(s) : Moricz AM , Kruzselyi D , Ott PG , Garadi Z , Beni S , Morlock GE , Bakonyi J |
| Ref : Journal of Chromatography A , 1635 :461727 , 2021 |
| Abstract : Giant goldenrod (Solidago gigantea Ait.) root extract was screened for bioactive compounds by high-performance thin-layer chromatography (HPTLC), coupled with effect-directed analysis including antibacterial (Bacillus subtilis F1276, B. subtilis subsp. spizizenii, Aliivibrio fischeri and Xanthomonas euvesicatoria), antifungal (Fusarium avenaceum) and enzyme inhibition (acetyl- and butyrylcholinesterases, alpha- and beta-glucosidases and alpha-amylase) assays. Compounds of six multipotent zones (Sg1-Sg6) were characterized by HPTLC-heated electrospray ionization-high-resolution mass spectrometry (HRMS) and HPTLC-Direct Analysis in Real Time-HRMS. Apart from zone Sg3, containing three compounds, a single characteristic compound was detectable in each bioactive zone. The bioassay-guided isolation using preparative-scale flash chromatography and high-performance liquid chromatography provided eight compounds that were identified by NMR spectroscopy as clerodane diterpenes. All isolates possessed inhibiting activity against at least one of the tested microorganisms. |
| ESTHER : Moricz_2021_J.Chromatogr.A_1635_461727 |
| PubMedSearch : Moricz_2021_J.Chromatogr.A_1635_461727 |
| PubMedID: 33338903 |
Moricz AM, Kruzselyi D, Ott PG, Garadi Z, Beni S, Morlock GE, Bakonyi J (2021)
Bioactive clerodane diterpenes of giant goldenrod (Solidago gigantea Ait.) root extract
Journal of Chromatography A
1635 :461727
Moricz AM, Kruzselyi D, Ott PG, Garadi Z, Beni S, Morlock GE, Bakonyi J (2021)
Journal of Chromatography A
1635 :461727