| Title : The Discovery of Fungal Polyene Macrolides via a Postgenomic Approach Reveals a Polyketide Macrocyclization by trans-Acting Thioesterase in Fungi - Morishita_2019_Org.Lett_21_4788 |
| Author(s) : Morishita Y , Zhang H , Taniguchi T , Mori K , Asai T |
| Ref : Org Lett , 21 :4788 , 2019 |
|
Abstract :
Heterologous expression of a unique biosynthetic gene cluster (BGC) comprising a highly reducing polyketide synthase and stand-alone thioesterase genes in Aspergillus oryzae enabled us to isolate a novel 34-membered polyene macrolide, phaeospelide A (1). This is the first isolation of a fungal polyene macrolide and the first demonstration of fungal aliphatic macrolide biosynthetic machinery. In addition, sequence similarity network analysis demonstrated the existence of a large number of BGCs for novel fungal macrolides. |
| PubMedSearch : Morishita_2019_Org.Lett_21_4788 |
| PubMedID: 31180682 |
| Gene_locus related to this paper: artpe-apmlb |
| Gene_locus | artpe-apmlb |
Morishita Y, Zhang H, Taniguchi T, Mori K, Asai T (2019)
The Discovery of Fungal Polyene Macrolides via a Postgenomic Approach Reveals a Polyketide Macrocyclization by trans-Acting Thioesterase in Fungi
Org Lett
21 :4788
Morishita Y, Zhang H, Taniguchi T, Mori K, Asai T (2019)
Org Lett
21 :4788