Title : Genomic minimalism in the early diverging intestinal parasite Giardia lamblia - Morrison_2007_Science_317_1921 |
Author(s) : Morrison HG , McArthur AG , Gillin FD , Aley SB , Adam RD , Olsen GJ , Best AA , Cande WZ , Chen F , Cipriano MJ , Davids BJ , Dawson SC , Elmendorf HG , Hehl AB , Holder ME , Huse SM , Kim UU , Lasek-Nesselquist E , Manning G , Nigam A , Nixon JE , Palm D , Passamaneck NE , Prabhu A , Reich CI , Reiner DS , Samuelson J , Svard SG , Sogin ML |
Ref : Science , 317 :1921 , 2007 |
Abstract :
The genome of the eukaryotic protist Giardia lamblia, an important human intestinal parasite, is compact in structure and content, contains few introns or mitochondrial relics, and has simplified machinery for DNA replication, transcription, RNA processing, and most metabolic pathways. Protein kinases comprise the single largest protein class and reflect Giardia's requirement for a complex signal transduction network for coordinating differentiation. Lateral gene transfer from bacterial and archaeal donors has shaped Giardia's genome, and previously unknown gene families, for example, cysteine-rich structural proteins, have been discovered. Unexpectedly, the genome shows little evidence of heterozygosity, supporting recent speculations that this organism is sexual. This genome sequence will not only be valuable for investigating the evolution of eukaryotes, but will also be applied to the search for new therapeutics for this parasite. |
PubMedSearch : Morrison_2007_Science_317_1921 |
PubMedID: 17901334 |
Gene_locus related to this paper: giaia-e1f0e1 , giaib-c6lwm0 , giaic-a8b7a3 , giaic-a8ba82 , giaic-a8bci8 , giaic-a8bfp3 , giaic-a8bni9 , giaic-a8bnj4 , giaic-d3kgs7 , giain-Q95WU5 , giala-ENC6 |
Morrison HG, McArthur AG, Gillin FD, Aley SB, Adam RD, Olsen GJ, Best AA, Cande WZ, Chen F, Cipriano MJ, Davids BJ, Dawson SC, Elmendorf HG, Hehl AB, Holder ME, Huse SM, Kim UU, Lasek-Nesselquist E, Manning G, Nigam A, Nixon JE, Palm D, Passamaneck NE, Prabhu A, Reich CI, Reiner DS, Samuelson J, Svard SG, Sogin ML (2007)
Genomic minimalism in the early diverging intestinal parasite Giardia lamblia
Science
317 :1921
Morrison HG, McArthur AG, Gillin FD, Aley SB, Adam RD, Olsen GJ, Best AA, Cande WZ, Chen F, Cipriano MJ, Davids BJ, Dawson SC, Elmendorf HG, Hehl AB, Holder ME, Huse SM, Kim UU, Lasek-Nesselquist E, Manning G, Nigam A, Nixon JE, Palm D, Passamaneck NE, Prabhu A, Reich CI, Reiner DS, Samuelson J, Svard SG, Sogin ML (2007)
Science
317 :1921