Mottaghipisheh_2021_Pharmaceuticals.(Basel)_14_

Reference

Title : Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review - Mottaghipisheh_2021_Pharmaceuticals.(Basel)_14_
Author(s) : Mottaghipisheh J , Taghrir H , Boveiri Dehsheikh A , Zomorodian K , Irajie C , Mahmoodi Sourestani M , Iraji A
Ref : Pharmaceuticals (Basel) , 14 : , 2021
Abstract :

Many flavonoids, as eminent phenolic compounds, have been commercialized and consumed as dietary supplements due to their incredible human health benefits. In the present study, a bioactive flavone glycoside linarin (LN) was designated to comprehensively overview its phytochemical and biological properties. LN has been characterized abundantly in the Cirsium, Micromeria, and Buddleja species belonging to Asteraceae, Lamiaceae, and Scrophulariaceae families, respectively. Biological assessments exhibited promising activities of LN, particularly, the remedial effects on central nervous system (CNS) disorders, whereas the remarkable sleep enhancing and sedative effects as well as AChE (acetylcholinesterase) inhibitory activity were highlighted. Of note, LN has indicated promising anti osteoblast proliferation and differentiation, thus a bone formation effect. Further biological and pharmacological assessments of LN and its optimized semi-synthetic derivatives, specifically its therapeutic characteristics on osteoarthritis and osteoporosis, might lead to uncovering potential drug candidates.

PubMedSearch : Mottaghipisheh_2021_Pharmaceuticals.(Basel)_14_
PubMedID: 34832886

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Citations formats

Mottaghipisheh J, Taghrir H, Boveiri Dehsheikh A, Zomorodian K, Irajie C, Mahmoodi Sourestani M, Iraji A (2021)
Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review
Pharmaceuticals (Basel) 14 :

Mottaghipisheh J, Taghrir H, Boveiri Dehsheikh A, Zomorodian K, Irajie C, Mahmoodi Sourestani M, Iraji A (2021)
Pharmaceuticals (Basel) 14 :