| Title : The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies - Mou_2013_J.Virol_87_9379 |
| Author(s) : Mou H , Raj VS , van Kuppeveld FJ , Rottier PJ , Haagmans BL , Bosch BJ |
| Ref : J Virol , 87 :9379 , 2013 |
|
Abstract :
The spike (S) protein of the recently emerged human Middle East respiratory syndrome coronavirus (MERS-CoV) mediates infection by binding to the cellular receptor dipeptidyl peptidase 4 (DPP4). Here we mapped the receptor binding domain in the S protein to a 231-amino-acid fragment (residues 358 to 588) by evaluating the interaction of spike truncation variants with receptor-expressing cells and soluble DPP4. Antibodies to this domain--much less so those to the preceding N-terminal region--efficiently neutralize MERS-CoV infection. |
| PubMedSearch : Mou_2013_J.Virol_87_9379 |
| PubMedID: 23785207 |
Mou H, Raj VS, van Kuppeveld FJ, Rottier PJ, Haagmans BL, Bosch BJ (2013)
The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies
J Virol
87 :9379
Mou H, Raj VS, van Kuppeveld FJ, Rottier PJ, Haagmans BL, Bosch BJ (2013)
J Virol
87 :9379