| Title : Molecular characterization and analysis of the operon encoding the antifungal lipopeptide bacillomycin D - Moyne_2004_FEMS.Microbiol.Lett_234_43 |
| Author(s) : Moyne AL , Cleveland TE , Tuzun S |
| Ref : FEMS Microbiology Letters , 234 :43 , 2004 |
|
Abstract :
Bacillus subtilis AU195 produces bacillomycin D, a cyclic lipopeptide that is an inhibitor of the aflatoxin producing fungus Aspergillus flavus. Sequence analysis of the bacillomycin D operon revealed four ORFs with the structural organization of the peptide synthetases. Disruption of ORF 2, which links the amino acid moiety to the b-amino fatty acid, resulted in the loss of antifungal activity. By comparing the sequence of bacillomycin D, iturin A and mycosubtilin operons, our results showed that intergenic module replacement have occurred between B. subtilis lipopeptide synthetases including the iturin family and the plipastatin and fengycin family. |
| PubMedSearch : Moyne_2004_FEMS.Microbiol.Lett_234_43 |
| PubMedID: 15109718 |
| Gene_locus related to this paper: bacsu-q6yk39 |
| Gene_locus | bacsu-q6yk39 |
Moyne AL, Cleveland TE, Tuzun S (2004)
Molecular characterization and analysis of the operon encoding the antifungal lipopeptide bacillomycin D
FEMS Microbiology Letters
234 :43
Moyne AL, Cleveland TE, Tuzun S (2004)
FEMS Microbiology Letters
234 :43