Mukaetova-Ladinska_2012_J.Alzheimers.Dis_32_431

We report a 16.5 increase in platelet immunoglobulin Ig content in subjects with Alzheimer's disease AD in relation to cognitively intact individuals p 0.021 whereas the plasma Ig levels were unaltered p 0.428 The upregulation of platelet Ig was not explained by age duration of dementia or degree of cognitive impairment However AD subjects treated with cholinesterase inhibitors n 21 had lower levels of platelet Ig p 0.009 than AD subjects not treated with anti-dementia drugs n 4 and similar to those of control subjects n 24 p 0.069 The anti-dementia treatment did not influence the plasma Ig levels p 0.177 These preliminary findings require further confirmation in studies on larger number of AD subjects with various stages of cognitive impairment and who would be assessed prior to initiation of and during cholinesterase inhibitor treatment.