| Title : Synthesis of 9-Aminoacridine Derivatives as Anti-Alzheimer Agents - Munawar_2016_Am.J.Alzheimers.Dis.Other.Demen_31_263 |
| Author(s) : Munawar R , Mushtaq N , Arif S , Ahmed A , Akhtar S , Ansari S , Meer S , Saify ZS , Arif M |
| Ref : Am J Alzheimers Dis Other Demen , 31 :263 , 2016 |
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Abstract :
In the present study, some 9-aminoacridine derivatives have been synthesized by condensation of 9-aminoacridine with substituted phenacyl, benzoyl, and benzyl halides (RM1-RM6). Compounds were investigated for acetylcholinesterase and butyrylcholinesterase inhibition potential, considering these enzymes playing a key role in Alzheimer's disease. All derivatives showed better inhibition of enzymes than the standard galantamine, whereas except RM4, all exhibit better results than tacrine, a well-known acridine derivative used for the treatment of Alzheimer's disease. |
| PubMedSearch : Munawar_2016_Am.J.Alzheimers.Dis.Other.Demen_31_263 |
| PubMedID: 26385945 |
Munawar R, Mushtaq N, Arif S, Ahmed A, Akhtar S, Ansari S, Meer S, Saify ZS, Arif M (2016)
Synthesis of 9-Aminoacridine Derivatives as Anti-Alzheimer Agents
Am J Alzheimers Dis Other Demen
31 :263
Munawar R, Mushtaq N, Arif S, Ahmed A, Akhtar S, Ansari S, Meer S, Saify ZS, Arif M (2016)
Am J Alzheimers Dis Other Demen
31 :263