| Title : Status of acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease and type 2 diabetes mellitus - Mushtaq_2014_CNS.Neurol.Disord.Drug.Targets_13_1432 |
| Author(s) : Mushtaq G , Greig NH , Khan JA , Kamal MA |
| Ref : CNS Neurol Disord Drug Targets , 13 :1432 , 2014 |
| Abstract : Both Alzheimer's disease (AD) and Type 2 diabetes mellitus (T2DM) share the presence of systemic and neuro-inflammation, enhanced production and accumulation of beta -amyloid peptide and abnormal levels of the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BCHE). Altered levels of AChE and BCHE both in AD as well as in T2DM imply that those two enzymes may be playing a pivotal role in the pathogenesis of the two disorders. AD and T2DM are both characterized by elevated levels of AChE and BCHE in the plasma. On the other hand, in AD the brain levels of AChE go down while those of BCHE go up, resulting in deregulation in balance between AChE and BCHE. This imbalance and change in the AChE/BCHE ratio causes cholinergic deficit in the brain, i.e. deficiency in the brain neurotransmitter acetylcholine. With better understanding of the inter-relationship of AChE and BCHE levels in normality as well as abnormality, AD and T2DM can be effectively treated. Thus, general cholinesterase inhibitors that inhibit both AChE and BCHE as well as highly selective BCHE inhibitors may have potential therapeutic benefits in the treatment of AD and other related dementias. |
| ESTHER : Mushtaq_2014_CNS.Neurol.Disord.Drug.Targets_13_1432 |
| PubMedSearch : Mushtaq_2014_CNS.Neurol.Disord.Drug.Targets_13_1432 |
| PubMedID: 25345511 |
Mushtaq G, Greig NH, Khan JA, Kamal MA (2014)
Status of acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease and type 2 diabetes mellitus
CNS Neurol Disord Drug Targets
13 :1432
Mushtaq G, Greig NH, Khan JA, Kamal MA (2014)
CNS Neurol Disord Drug Targets
13 :1432