Title : Biliary excretion of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) and metabolites by Fischer 344 rats - Musser_2003_Cancer.Chemother.Pharmacol_52_139 |
Author(s) : Musser SM , Egorin MJ , Zuhowski EG , Hamburger DR , Parise RA , Covey JM , White KD , Eiseman JL |
Ref : Cancer Chemother Pharmacol , 52 :139 , 2003 |
Abstract :
PURPOSE: 17-(Allylamino)-17-demethoxygeldanamycin (17AAG), an analogue of the benzoquinone ansamycin geldanamycin, has been extensively studied preclinically and is being evaluated clinically. Studies were performed to define the biliary excretion of 17AAG after i.v. delivery to rats, and to characterize the metabolites of 17AAG observed in rat bile. MATERIALS AND |
PubMedSearch : Musser_2003_Cancer.Chemother.Pharmacol_52_139 |
PubMedID: 12761648 |
Musser SM, Egorin MJ, Zuhowski EG, Hamburger DR, Parise RA, Covey JM, White KD, Eiseman JL (2003)
Biliary excretion of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) and metabolites by Fischer 344 rats
Cancer Chemother Pharmacol
52 :139
Musser SM, Egorin MJ, Zuhowski EG, Hamburger DR, Parise RA, Covey JM, White KD, Eiseman JL (2003)
Cancer Chemother Pharmacol
52 :139