| Title : Synthesis and cholinesterase activity of phenylcarbamates related to Rivastigmine, a therapeutic agent for Alzheimer's disease - Mustazza_2002_Eur.J.Med.Chem_37_91 |
| Author(s) : Mustazza C , Borioni A , Giudice MR , Gatta F , Ferretti R , Meneguz A , Volpe MT , Lorenzini P |
| Ref : Eur Journal of Medicinal Chemistry , 37 :91 , 2002 |
|
Abstract :
In order to develop new cholinesterase agents effective against Alzheimer's disease (AD) we synthesized some phenylcarbamates structurally related to Rivastigmine and evaluated their in vitro and in vivo biological activity. Among the compounds which displayed the most significant in vitro activity, 1-[1-(3-dimethylcarbamoyloxyphenyl)ethyl]piperidine (31b), in addition to a simple and cheaper synthesis, showed lower toxicity and very similar therapeutic index in comparison with Rivastigmine. |
| PubMedSearch : Mustazza_2002_Eur.J.Med.Chem_37_91 |
| PubMedID: 11858843 |
Mustazza C, Borioni A, Giudice MR, Gatta F, Ferretti R, Meneguz A, Volpe MT, Lorenzini P (2002)
Synthesis and cholinesterase activity of phenylcarbamates related to Rivastigmine, a therapeutic agent for Alzheimer's disease
Eur Journal of Medicinal Chemistry
37 :91
Mustazza C, Borioni A, Giudice MR, Gatta F, Ferretti R, Meneguz A, Volpe MT, Lorenzini P (2002)
Eur Journal of Medicinal Chemistry
37 :91