| Title : Curcumin prevents cigarette smoke extract induced cognitive impairment - Muthuraman_2019_Front.Biosci.(Elite.Ed)_11_109 |
| Author(s) : Muthuraman A , Thilagavathi L , Jabeen S , Ravishankar SB , Ahmed SS , George T , Rishitha N , Paramakrishnan N |
| Ref : Front Biosci (Elite Ed) , 11 :109 , 2019 |
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Abstract :
Curcumin is a major phytochemical constituent in Curcuma longa, an herbaceous perennial plant of Zingiberaceae family, which exhibits anti-oxidant, anti-inflammatory and immunomodulatory properties. Here, we studied the therapeutic action of curcumin against CSE induced cognitive impairment in zebrafish. Montelukast (20 mg/kg), a cysteinyl-leukotriene receptor blocker was used as a reference drug. CSE exposure induced biochemical changes revealed that raise the brain acetylcholinesterase activity and lipid peroxidative products; and decrease the reduced glutathione levels in brain samples. Curcumin also protected against CSE induced neurocognitive impairment. These data suggest that curcumin can serve as a phytochemical constituent against CSE induced neurocognitive impairment. |
| PubMedSearch : Muthuraman_2019_Front.Biosci.(Elite.Ed)_11_109 |
| PubMedID: 30468642 |
Muthuraman A, Thilagavathi L, Jabeen S, Ravishankar SB, Ahmed SS, George T, Rishitha N, Paramakrishnan N (2019)
Curcumin prevents cigarette smoke extract induced cognitive impairment
Front Biosci (Elite Ed)
11 :109
Muthuraman A, Thilagavathi L, Jabeen S, Ravishankar SB, Ahmed SS, George T, Rishitha N, Paramakrishnan N (2019)
Front Biosci (Elite Ed)
11 :109