Myhrer_2004_Eur.J.Pharmacol_483_271

Reference

Title : Cognitive side effects in rats caused by pharmacological agents used to prevent soman-induced lethality - Myhrer_2004_Eur.J.Pharmacol_483_271
Author(s) : Myhrer T , Enger S , Aas P
Ref : European Journal of Pharmacology , 483 :271 , 2004
Abstract :

It is important that prophylactics used to protect military and emergency personnel against lethal doses of nerve agents do not by themselves produce impairment of cognitive capability. The purpose of the present study was to examine whether physostigmine, scopolamine, and various doses of procyclidine might reduce rats' innate preference for novelty. When these drugs were tested separately, the results showed that physostigmine (0.1 mg/kg) and procyclidine (3 mg/kg) did not affect preference for novelty, whereas scopolamine (0.15 mg/kg) and procyclidine in a higher dose (6 mg/kg) resulted in a preference deficit (Experiment 1). In Experiment 2, the combination of physostigmine and scopolamine or physostigmine and procyclidine (6 mg/kg) caused a marked deficit in preference for novelty. A much milder deficit was observed when physostigmine was combined with lower doses (1 or 3 mg/kg) of procyclidine. The latter combinations also had milder adverse impact on the animals' interest in the test environment and activity measures than the former combinations. By combining physostigmine with anticholinergics, a potentiation of adverse effects on behavior was seen. It is concluded that a slight cognitive impairment might be unavoidable with effective prophylactics.

PubMedSearch : Myhrer_2004_Eur.J.Pharmacol_483_271
PubMedID: 14729117

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Citations formats

Myhrer T, Enger S, Aas P (2004)
Cognitive side effects in rats caused by pharmacological agents used to prevent soman-induced lethality
European Journal of Pharmacology 483 :271

Myhrer T, Enger S, Aas P (2004)
European Journal of Pharmacology 483 :271