Na_2013_Int.J.Cancer_133_408

Reference

Title : Human liver carboxylesterase 1 outperforms alpha-fetoprotein as biomarker to discriminate hepatocellular carcinoma from other liver diseases in Korean patients - Na_2013_Int.J.Cancer_133_408
Author(s) : Na K , Jeong SK , Lee MJ , Cho SY , Kim SA , Song SY , Kim H , Kim KS , Lee HW , Paik YK
Ref : International Journal of Cancer , 133 :408 , 2013
Abstract :

Although alpha-fetoprotein (AFP) is currently the major serologic biomarker for hepatocellular carcinoma (HCC), it cannot efficiently distinguish this cancer from other forms of liver disease in early diagnosis due to its low sensitivity. The aim of this study is to compare sensitivity and specificity of human carboxylesterase 1 (hCE1) and AFP biomarker. Antibody-based assays for hCE1 and AFP were used to test both biomarkers with respect to diagnostic efficiency, Youden's index and the area under the curve (AUC) through receiver operating characteristic (ROC) analysis in plasma from 208 patients with HCC (n=57), liver cirrhosis (n=27), chronic hepatitis (n=37), cholangiocarcinoma (n=22), gastric cancer (n=31) and pancreatic cancer (n=34), along with 52 healthy donors (HDs). The levels of hCE1 were significantly higher in patients with HCC than HDs and the other diseases (p<0.005), further verified by AUC values and Youden's index. In the set of HCC versus liver cirrhosis the AUC values were 0.744 (AFP), 0.918 (hCE1) and 0.938 (combination of AFP and hCE1), respectively. These results indicate that hCE1 is not only a more potent and specific marker in distinguishing cancer from liver diseases, in particular cirrhosis, but the combination of hCE1 and AFP shows also synergistic potential for greater sensitivity and specificity in early diagnosis. Therefore the antibody-based hCE1 assay appears to have high diagnostic efficiency for discriminating HCC from other forms of liver disease. It is now feasible to further validate this novel plasma-based biomarker in the large cohort we assembled.

PubMedSearch : Na_2013_Int.J.Cancer_133_408
PubMedID: 23319432

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Citations formats

Na K, Jeong SK, Lee MJ, Cho SY, Kim SA, Song SY, Kim H, Kim KS, Lee HW, Paik YK (2013)
Human liver carboxylesterase 1 outperforms alpha-fetoprotein as biomarker to discriminate hepatocellular carcinoma from other liver diseases in Korean patients
International Journal of Cancer 133 :408

Na K, Jeong SK, Lee MJ, Cho SY, Kim SA, Song SY, Kim H, Kim KS, Lee HW, Paik YK (2013)
International Journal of Cancer 133 :408