| Title : An amino acid substitution on the second acetylcholinesterase in the pirimicarb-resistant strains of the peach potato aphid, Myzus persicae - Nabeshima_2003_Biochem.Biophys.Res.Commun_307_15 |
| Author(s) : Nabeshima T , Kozaki T , Tomita T , Kono Y |
| Ref : Biochemical & Biophysical Research Communications , 307 :15 , 2003 |
|
Abstract :
cDNAs encoding two acetylcholinesterases (AChEs) were isolated from the peach potato aphid, Myzus persicae. MpAChE1 was orthologous and MpAChE2 was paralogous with the ace of Drosophila melanogaster. The deduced amino acid sequence of MpAChE1 cDNA was identical between the pirimicarb susceptible and resistant strains. However, a single amino acid substitution of Ser431Phe on MpAchE2 was found in the pirimicarb resistant strains. This substitution was located in the acyl pocket of the enzyme and was thought to alter the ligand specificity. |
| PubMedSearch : Nabeshima_2003_Biochem.Biophys.Res.Commun_307_15 |
| PubMedID: 12849975 |
| Gene_locus related to this paper: myzpe-ACHE , myzpe-ACHEm |
| Mutation | S431F_myzpe-ACHEm |
| Gene_locus | myzpe-ACHE myzpe-ACHEm |
Nabeshima T, Kozaki T, Tomita T, Kono Y (2003)
An amino acid substitution on the second acetylcholinesterase in the pirimicarb-resistant strains of the peach potato aphid, Myzus persicae
Biochemical & Biophysical Research Communications
307 :15
Nabeshima T, Kozaki T, Tomita T, Kono Y (2003)
Biochemical & Biophysical Research Communications
307 :15