| Title : Synthesis of potent neuroprotective butenolides based on plant smoke derived 3,4,5-Trimethylfuran-2(5H)-one and 3-methyl-2H-furo[2,3-c]pyrone-2-one - Naidoo_2019_Phytochemistry_163_187 |
| Author(s) : Naidoo D , Posta M , Roy A , Kulkarni M , Van Staden J |
| Ref : Phytochemistry , 163 :187 , 2019 |
|
Abstract :
Smoke derived karrikinolide and trimethylbutenolide exerted neuroprotective effects against monoamine oxidase and acetylcholinesterase. Synthesis of potent analogs was achieved. Sulphur substitution in the bicyclic ring structure of KAR1 displayed the most encouraging activity returning IC50 values of 13.75+/-0.001muM and 0.03+/-0.02muM for monoamine oxidase A and B and 0.08+/-0.006muM for acetylcholinesterase. Neuroprotective butenolides may be particularly useful in the treatment of depressive disorders, Alzheimer's and Parkinson's diseases. |
| PubMedSearch : Naidoo_2019_Phytochemistry_163_187 |
| PubMedID: 31014820 |
Naidoo D, Posta M, Roy A, Kulkarni M, Van Staden J (2019)
Synthesis of potent neuroprotective butenolides based on plant smoke derived 3,4,5-Trimethylfuran-2(5H)-one and 3-methyl-2H-furo[2,3-c]pyrone-2-one
Phytochemistry
163 :187
Naidoo D, Posta M, Roy A, Kulkarni M, Van Staden J (2019)
Phytochemistry
163 :187