| Title : A concise synthesis of physostigmine from skatole and activated aziridine via alkylative cyclization - Nakagawa_2000_Org.Lett_2_953 |
| Author(s) : Nakagawa M , Kawahara M |
| Ref : Org Lett , 2 :953 , 2000 |
|
Abstract :
A concise synthetic route to physostigmine has been developed, where the key step relies on the alkylative cyclization of 1,3-dimethylindole with (Z)-aziridine catalyzed by Sc(OTf)3 and TMSCI in dichloromethane at -30 degrees C, to give 8 in 90% yield, which, in turn, can be readily converted into physostigmine. |
| PubMedSearch : Nakagawa_2000_Org.Lett_2_953 |
| PubMedID: 10768195 |
Nakagawa M, Kawahara M (2000)
A concise synthesis of physostigmine from skatole and activated aziridine via alkylative cyclization
Org Lett
2 :953
Nakagawa M, Kawahara M (2000)
Org Lett
2 :953