Nakahara_1990_Brain.Res_507_172

Reference

Title : Central muscarinic activities of an M1-selective agonist: preferential effect on reversal of amnesia - Nakahara_1990_Brain.Res_507_172
Author(s) : Nakahara N , Fujise N , Kawanishi G , Mizobe F
Ref : Brain Research , 507 :172 , 1990
Abstract :

Effects of FKS-508 (AF102B; cis-2-methylspiro (1,3-oxathiolane-5,3')-quinuclidine), a novel M1-selective agonist, on central muscarinic responses in mice were examined in comparison with oxotremorine. FKS-508 was slightly less potent (6 times) in reversal of scopolamine-induced amnesia (passive avoidance failure), but far less potent (260 and 55 times) in producing hypothermia and tremor than oxotremorine. These results show that the selective M1 agonist FKS-508 differentiates highly between the central muscarinic effects.

PubMedSearch : Nakahara_1990_Brain.Res_507_172
PubMedID: 2302575

Related information

Citations formats

Nakahara N, Fujise N, Kawanishi G, Mizobe F (1990)
Central muscarinic activities of an M1-selective agonist: preferential effect on reversal of amnesia
Brain Research 507 :172

Nakahara N, Fujise N, Kawanishi G, Mizobe F (1990)
Brain Research 507 :172