| Title : Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice - Nakajima_2007_J.Pharmacol.Sci_105_122 |
| Author(s) : Nakajima A , Yamakuni T , Haraguchi M , Omae N , Song SY , Kato C , Nakagawasai O , Tadano T , Yokosuka A , Mimaki Y , Sashida Y , Ohizumi Y |
| Ref : J Pharmacol Sci , 105 :122 , 2007 |
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Abstract :
We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer's disease. Here, we examined the effects of nobiletin on OBX-induced cholinergic neurodegeneration in mice. OBX mice showed reduced acetylcholinesterase (AChE) staining and choline acetyltransferase (ChAT) expression in the hippocampus. An 11-day administration of nobiletin rescued OBX-induced decrease in the density of AChE-staining and ChAT expression in the hippocampus. These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice. |
| PubMedSearch : Nakajima_2007_J.Pharmacol.Sci_105_122 |
| PubMedID: 17895593 |
Nakajima A, Yamakuni T, Haraguchi M, Omae N, Song SY, Kato C, Nakagawasai O, Tadano T, Yokosuka A, Mimaki Y, Sashida Y, Ohizumi Y (2007)
Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice
J Pharmacol Sci
105 :122
Nakajima A, Yamakuni T, Haraguchi M, Omae N, Song SY, Kato C, Nakagawasai O, Tadano T, Yokosuka A, Mimaki Y, Sashida Y, Ohizumi Y (2007)
J Pharmacol Sci
105 :122