Naki_2023_J.Microencapsul__1

Reference

Title : Polymer Drug Conjugates Containing Memantine, Tacrine And Cinnamic Acid: Promising Nanotherapeutics for the Treatment of Alzheimer's Disease - Naki_2023_J.Microencapsul__1
Author(s) : Naki T , Matshe WMR , Balogun MO , Sinha Ray S , Egieyeh SA , Aderibigbe BA
Ref : J Microencapsul , :1 , 2023
Abstract :

AIM: To prepare polymer-drug conjugates containing a combination of memantine, tacrine, and E)-N-(3-aminopropyl)cinnamide, promising therapeutics for the treatment of neurodegenerative disorders. METHODS: The conjugates were characterized by (1)HNMR, particle size analysis, SEM, LC-MS, TEM/EDX, and XRD, followed by in vitro anti-acetylcholinesterase and drug release studies. RESULTS: (1)H NMR analysis revealed successful drug conjugation with drug mass percentages in the range of 1.3-6.0% w/w. The drug release from the conjugates was sustained for 10 h in the range of 20-36%. The conjugates' capability to inhibit acetylcholinesterase (AChE) activity was significant with 1C(50) values in the range of 13-44.4 microm which was more effective than tacrine (1C(50) =1698.8 microm). The docking studies further confirmed that the conjugation of the drugs into the polymer improved their anti-acetylcholinesterase activity. CONCLUSION: The drug release profile, particle sizes, and in vitro studies revealed that the conjugates are promising therapeutics for treating neurodegenerative disorders.

PubMedSearch : Naki_2023_J.Microencapsul__1
PubMedID: 36622880

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Citations formats

Naki T, Matshe WMR, Balogun MO, Sinha Ray S, Egieyeh SA, Aderibigbe BA (2023)
Polymer Drug Conjugates Containing Memantine, Tacrine And Cinnamic Acid: Promising Nanotherapeutics for the Treatment of Alzheimer's Disease
J Microencapsul :1

Naki T, Matshe WMR, Balogun MO, Sinha Ray S, Egieyeh SA, Aderibigbe BA (2023)
J Microencapsul :1