Title : Inhibition of agrin-mediated acetylcholine receptor clustering by utrophin C-terminal peptides - Namba_1996_Genes.Cells_1_755 |
Author(s) : Namba T , Scheller RH |
Ref : Genes Cells , 1 :755 , 1996 |
Abstract :
BACKGROUND: Agrin is an extracellular matrix protein that is required for neuromuscular synaptogenesis and is particularly important in the clustering of acetylcholine receptors at post-synaptic sites. Little is known about the signal transduction pathway of agrin-mediated receptor clustering, although cytoskeletal elements and a dystrophin associated glycoprotein complex (DGC) have been implicated. Because agrin binds to alpha-dystroglycan, a member of the DGC, and the DGC is linked to actin through utrophin at postsynaptic sites, it has been suggested that binding of utrophin to the DGC plays a central role in agrin mediated receptor clustering. |
PubMedSearch : Namba_1996_Genes.Cells_1_755 |
PubMedID: 9077444 |
Namba T, Scheller RH (1996)
Inhibition of agrin-mediated acetylcholine receptor clustering by utrophin C-terminal peptides
Genes Cells
1 :755
Namba T, Scheller RH (1996)
Genes Cells
1 :755