Nampoothiri_2015_Behav.Neurol_2015_210169

Reference

Title : Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats - Nampoothiri_2015_Behav.Neurol_2015_210169
Author(s) : Nampoothiri M , John J , Kumar N , Mudgal J , Nampurath GK , Chamallamudi MR
Ref : Behav Neurol , 2015 :210169 , 2015
Abstract :

Objectives. Aluminium, a neurotoxic agent in humans, has been implicated in the pathogenesis of neurodegenerative disorders. In this study, we examined the behavioral and biochemical effects of aluminium in rats with special emphasis on memory centres, namely, hippocampus and frontal cortex. Further, the effect of simvastatin treatment on aluminium intoxication was evaluated. Methods. Rats were exposed to aluminium chloride (AlCl3) for 60 days. Simvastatin (10 mg/kg/p.o.) and rivastigmine (1 mg/kg/p.o.) were administered daily prior to AlCl3. Behavioral parameters were assessed using Morris water maze test and actophotometer followed by biochemical investigations, namely, acetylcholinesterase (AChE) activity, TNF-alpha level, antioxidant enzymes (GSH, catalase), lipid peroxidation, and nitrite level in hippocampus and frontal cortex. Triglycerides, total cholesterol, LDL, and HDL levels in serum were also determined. Key Findings. Simvastatin treatment improved cognitive function and locomotor activity in rats. Simvastatin reversed hyperlipidemia and significantly rectified the deleterious effect of AlCl3 on AChE activity. Further, in hippocampus and frontal cortex, aluminium-induced elevation in nitrite and TNF-alpha and reduction in antioxidant enzymes were inhibited by simvastatin. Conclusion. To conclude, the present study suggests that simvastatin per se protects the neurons in hippocampus and frontal cortex from AlCl3, an environmental toxin.

PubMedSearch : Nampoothiri_2015_Behav.Neurol_2015_210169
PubMedID: 25802481

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Citations formats

Nampoothiri M, John J, Kumar N, Mudgal J, Nampurath GK, Chamallamudi MR (2015)
Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats
Behav Neurol 2015 :210169

Nampoothiri M, John J, Kumar N, Mudgal J, Nampurath GK, Chamallamudi MR (2015)
Behav Neurol 2015 :210169