Ncir_2017_Arch.Physiol.Biochem__1

Reference

Title : In vitro and in vivo studies of Allium sativum extract against deltamethrin-induced oxidative stress in rats brain and kidney - Ncir_2017_Arch.Physiol.Biochem__1
Author(s) : Ncir M , Saoudi M , Sellami H , Rahmouni F , Lahyani A , Makni Ayadi F , El Feki A , Allagui MS
Ref : Arch Physiol Biochem , :1 , 2017
Abstract :

The present study investigated the in vitro and the in vivo antioxidant capacities of Allium sativum (garlic) extract against deltamethrin-induced oxidative damage in rat's brain and kidney. The in vitro result showed that highest extraction yield was achieved with methanol (20.08%). Among the tested extracts, the methanol extract exhibited the highest total phenolic, flavonoids contents and antioxidant activity. The in vivo results showed that deltamethrin treatment caused an increase of the acetylcholinesterase level (AChE) in brain and plasma, the brain and kidney conjugated dienes and lipid peroxidation (LPO) levels as compared to control group. The antioxidant enzymes results showed that deltamethrin treatment induced a significantly decrease (p < 0.01) in brain and kidney antioxidant enzymes as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) to control group. The co-administration of garlic extract reduced the toxic effects in brain and kidney tissues induced by deltamethrin.

PubMedSearch : Ncir_2017_Arch.Physiol.Biochem__1
PubMedID: 28920707

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Citations formats

Ncir M, Saoudi M, Sellami H, Rahmouni F, Lahyani A, Makni Ayadi F, El Feki A, Allagui MS (2017)
In vitro and in vivo studies of Allium sativum extract against deltamethrin-induced oxidative stress in rats brain and kidney
Arch Physiol Biochem :1

Ncir M, Saoudi M, Sellami H, Rahmouni F, Lahyani A, Makni Ayadi F, El Feki A, Allagui MS (2017)
Arch Physiol Biochem :1