Neher_1975_Proc.Natl.Acad.Sci.U.S.A_72_2140

Reference

Title : Voltage-dependence of drug-induced conductance in frog neuromuscular junction - Neher_1975_Proc.Natl.Acad.Sci.U.S.A_72_2140
Author(s) : Neher E , Sakmann B
Ref : Proc Natl Acad Sci U S A , 72 :2140 , 1975
Abstract :

Membrane currents from voltage-clamped frog muscle fibers were recorded during iontophoretic application of steady doses of carbachol, acetylcholine, and suberyldicholine to the endplate region. In the presence of these drugs, an exponentially relaxing current was observed after step changes of membrane potential. The time constant of relaxation was found to be voltage-dependent. It was equal to the time constant obtained from the autocorrelation function of drug-induced conductance fluctuations measured under similar conditions. Analysis of instantaneous current at the on- and offsets of voltageclamp pulses showed that there is no shift in equilibrium potential during the pulses.

PubMedSearch : Neher_1975_Proc.Natl.Acad.Sci.U.S.A_72_2140
PubMedID: 1079601

Related information

Citations formats

Neher E, Sakmann B (1975)
Voltage-dependence of drug-induced conductance in frog neuromuscular junction
Proc Natl Acad Sci U S A 72 :2140

Neher E, Sakmann B (1975)
Proc Natl Acad Sci U S A 72 :2140