Neumann_1984_Biochem.Biophys.Res.Commun_121_673

Reference

Title : Anti-acetylcholine receptor response achieved by immunization with a synthetic peptide from the receptor sequence - Neumann_1984_Biochem.Biophys.Res.Commun_121_673
Author(s) : Neumann D , Fridkin M , Fuchs S
Ref : Biochemical & Biophysical Research Communications , 121 :673 , 1984
Abstract :

A synthetic peptide corresponding to the first twenty amino acids of the N-terminal region from the alpha-subunit of the Torpedo acetylcholine receptor cross reacts with antibodies to the receptor. A conjugate of this peptide to bovine serum albumin elicits in rabbits an immune response towards the synthetic peptide as well as towards the acetylcholine receptor. Blotting experiments demonstrate that the antipeptide antibodies react exclusively with the alpha-subunit of the acetylcholine receptor. Antibodies against synthetic peptides from various regions of the receptor sequence may provide useful reagents for structural and developmental analysis of the acetylcholine receptor as well as for the regulation of experimental autoimmune myasthenia gravis.

PubMedSearch : Neumann_1984_Biochem.Biophys.Res.Commun_121_673
PubMedID: 6203534

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Citations formats

Neumann D, Fridkin M, Fuchs S (1984)
Anti-acetylcholine receptor response achieved by immunization with a synthetic peptide from the receptor sequence
Biochemical & Biophysical Research Communications 121 :673

Neumann D, Fridkin M, Fuchs S (1984)
Biochemical & Biophysical Research Communications 121 :673