| Title : Click-based synthesis and proteomic profiling of lipstatin analogues - Ngai_2010_Chem.Commun.(Camb)_46_8335 |
| Author(s) : Ngai MH , Yang PY , Liu K , Shen Y , Wenk MR , Yao SQ , Lear MJ |
| Ref : Chem Commun (Camb) , 46 :8335 , 2010 |
|
Abstract :
Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death. |
| PubMedSearch : Ngai_2010_Chem.Commun.(Camb)_46_8335 |
| PubMedID: 20577697 |
Ngai MH, Yang PY, Liu K, Shen Y, Wenk MR, Yao SQ, Lear MJ (2010)
Click-based synthesis and proteomic profiling of lipstatin analogues
Chem Commun (Camb)
46 :8335
Ngai MH, Yang PY, Liu K, Shen Y, Wenk MR, Yao SQ, Lear MJ (2010)
Chem Commun (Camb)
46 :8335