| Title : Ring-expansion synthesis and crystal structure of dimethyl 4-ethyl-1,4,5,6,7,8-hexa-hydro-azonino[5,6-b]indole-2,3-di-carboxyl-ate - Nguyen_2017_Acta.Crystallogr.E.Crystallogr.Commun_73_338 |
| Author(s) : Nguyen VT , Sorokina EA , Listratova AV , Voskressensky LG , Lobanov NN , Dorovatovskii PV , Zubavichus YV , Khrustalev VN |
| Ref : Acta Crystallographica E Crystallogr Commun , 73 :338 , 2017 |
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Abstract :
The title compound, C20H24N2O4, is the product of a ring-expansion reaction from a seven-membered hexa-hydro-azepine to a nine-membered azonine. The azonine ring of the mol-ecule adopts a chair-boat conformation. In the crystal, mol-ecules are linked by bifurcated N-Hcdots, three dots, centered(O,O) hydrogen bonds, generating [010] zigzag chains. The title compound shows inhibitory activity against acetyl-cholinesterase and butyrylcholinesterase, and might be considered as a candidate for the design of new types of anti-Alzheimer's drugs. |
| PubMedSearch : Nguyen_2017_Acta.Crystallogr.E.Crystallogr.Commun_73_338 |
| PubMedID: 28316803 |
Nguyen VT, Sorokina EA, Listratova AV, Voskressensky LG, Lobanov NN, Dorovatovskii PV, Zubavichus YV, Khrustalev VN (2017)
Ring-expansion synthesis and crystal structure of dimethyl 4-ethyl-1,4,5,6,7,8-hexa-hydro-azonino[5,6-b]indole-2,3-di-carboxyl-ate
Acta Crystallographica E Crystallogr Commun
73 :338
Nguyen VT, Sorokina EA, Listratova AV, Voskressensky LG, Lobanov NN, Dorovatovskii PV, Zubavichus YV, Khrustalev VN (2017)
Acta Crystallographica E Crystallogr Commun
73 :338