Nguyen_2017_Bioorg.Chem_72_293

A new ellagitannin, agritannin (1), a new flavone glycoside, agriflavone (2), and another flavone glycoside with spectroscopic data reported for the first time, kaempferol-3-O-[(S)-3-hydroxy-3-methylglutaryl (1-->6)]-beta-d-glucoside (3), along with 16 known compounds were isolated from the aerial parts of Agrimonia pilosa Ledeb. These compounds were evaluated for PTP1B inhibitory activity. Among them, compounds 9 and 18 displayed potential inhibitory activity against PTP1B with IC50 values of 7.14+/-1.75 and 7.73+/-0.24muM, respectively. In addition, compound 1 showed significant inhibitory effect with an IC50 value of 17.03+/-0.09muM. Furthermore, these compounds were tested in AChE inhibitory assays. Most of them were found to have moderate inhibitory effects, with IC50 values ranging from 60.20+/-1.09 to 92.85+/-1.12muM. Except compounds 3, 8, and 18 were inactive.