Title : A new flavonoid from the leaves of Garcinia mckeaniana Craib and alpha-glucosidase and acetylcholinesterase inhibitory activities - Nguyen_2021_Nat.Prod.Res__1 |
Author(s) : Nguyen TTH , Nguyen VT , Van Cuong P , Nguyen Thanh T , Le Thi TA , Mai Huong DT , Truong BN , Litaudon M , Ninh The S |
Ref : Nat Prod Res , :1 , 2021 |
Abstract :
From the ethyl acetate extract (EtOAc) of the Vietnamese Garcinia mckeaniana leaves, a new flavone 8-C-glycoside 2'',6''-di-O-acetylvitexin (1), together with six known analogs 2-7 were isolated. Their structures were determined by spectral methods and compared with literature data. In alpha-glucosidase inhibitory assay, the EtOAc extract and its flavone and biflavone derivatives possessed the significant IC(50) range of 9.17-97.53 microM, as compared with that of the positive control acarbose (249 microM). Flavones and biflavones showed are better than flavone glycosides in both alpha-glucosidase and acetylcholinesterase inhibitory activities. |
PubMedSearch : Nguyen_2021_Nat.Prod.Res__1 |
PubMedID: 33939580 |
Nguyen TTH, Nguyen VT, Van Cuong P, Nguyen Thanh T, Le Thi TA, Mai Huong DT, Truong BN, Litaudon M, Ninh The S (2021)
A new flavonoid from the leaves of Garcinia mckeaniana Craib and alpha-glucosidase and acetylcholinesterase inhibitory activities
Nat Prod Res
:1
Nguyen TTH, Nguyen VT, Van Cuong P, Nguyen Thanh T, Le Thi TA, Mai Huong DT, Truong BN, Litaudon M, Ninh The S (2021)
Nat Prod Res
:1