| Title : Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population - Niare_2002_Science_298_213 |
| Author(s) : Niare O , Markianos K , Volz J , Oduol F , Toure A , Bagayoko M , Sangare D , Traore SF , Wang R , Blass C , Dolo G , Bouare M , Kafatos FC , Kruglyak L , Toure YT , Vernick KD |
| Ref : Science , 298 :213 , 2002 |
|
Abstract :
Successful propagation of the malaria parasite Plasmodium falciparum within a susceptible mosquito vector is a prerequisite for the transmission of malaria. A field-based genetic analysis of the major human malaria vector, Anopheles gambiae, has revealed natural factors that reduce the transmission of P. falciparum. Differences in P. falciparum oocyst numbers between mosquito isofemale families fed on the same infected blood indicated a large genetic component affecting resistance to the parasite, and genome-wide scanning in pedigrees of wild mosquitoes detected segregating resistance alleles. The apparently high natural frequency of resistance alleles suggests that malaria parasites (or a similar pathogen) exert a significant selective pressure on vector populations. |
| PubMedSearch : Niare_2002_Science_298_213 |
| PubMedID: 12364806 |
Niare O, Markianos K, Volz J, Oduol F, Toure A, Bagayoko M, Sangare D, Traore SF, Wang R, Blass C, Dolo G, Bouare M, Kafatos FC, Kruglyak L, Toure YT, Vernick KD (2002)
Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population
Science
298 :213
Niare O, Markianos K, Volz J, Oduol F, Toure A, Bagayoko M, Sangare D, Traore SF, Wang R, Blass C, Dolo G, Bouare M, Kafatos FC, Kruglyak L, Toure YT, Vernick KD (2002)
Science
298 :213