Niimi_2019_Parkinsonism.Relat.Disord_61_132

INTRODUCTION: Recent studies have indicated that lysosomal dysfunction contributes to the development of idiopathic Parkinson's disease (PD). It is uncertain whether dysregulation of serum lysosomal acid hydrolase activity exists in sporadic PD patients compared with normal controls (NCs) and parkinsonian syndrome (PS) patients. METHODS: Sporadic PD patients without GBA1 mutations (n=68) were matched with normal controls (n=45), and parkinsonian syndrome patients (n=32) in terms of family history, age, and sex. We measured the activities of lysosomal enzymes, alpha-galactosidase, beta-galactosidase, and beta-hexosaminidase and examined the possible correlations between lysosomal acid hydrolase activities with age in NCs, PD, and PS patients. RESULTS: beta-Galactosidase activity was significantly higher in the PD and PS than in the NC group (P<0.001). The beta-galactosidase to alpha-galactosidase and beta-hexosaminidase to beta-galactosidase activity ratios were more useful for distinguishing PD and PS patients from NCs (P<0.0001). Furthermore, alpha-galactosidase activity was significantly higher in PS patients than both PD and NC groups (p=0.04). beta-Galactosidase and alpha-galactosidase activities exhibited a statistically significant negative correlation with age in NCs, and beta-hexosaminidase activity showed a positive correlation with age in PS. However, PD patients did not show any of these correlations. CONCLUSION: Our results suggest the presence of an unknown regulatory mechanism(s) of serum acid hydrolase activities with aging in the normal population and abnormalities in their regulation in PD and PS patients. However, the pattern of dysregulation in these two groups is different. Thus, serum lysosomal acid hydrolase activity can be used as a peripheral biomarker for PD.