Nilsson_1995_J.Med.Chem_38_473

Reference

Title : 3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships - Nilsson_1995_J.Med.Chem_38_473
Author(s) : Nilsson BM , Sundquist S , Johansson G , Nordvall G , Glas G , Nilvebrant L , Hacksell U
Ref : Journal of Medicinal Chemistry , 38 :473 , 1995
Abstract :

A number of 3-heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives have been prepared and evaluated for muscarinic and antimuscarinic properties. The affinities of the new compounds (13, 14, 16-32, and 36-52a,b) were tested in homogenates of cerebral cortex, heart, parotid gland, and urinary bladder from guinea pigs using (-)-[3H]-3-quinuclidinyl benzilate [(-)-[3H]QNB] as the radioligand and in a functional assay using isolated guinea pig urinary bladder. The present compounds behaved as competitive muscarinic antagonists in the urinary bladder. The highest receptor binding affinity, Ki (cortex) = 9.6 nM, was observed for 3-(2-benzofuranyl)quinuclidin-2-ene (31). The corresponding 3-benzofuranyl (36) and 3-benzothienyl (37) homologues had about 3.5-fold lower affinity for cortical muscarinic receptors. All quinuclidin-3-ol derivatives (14 and 16-25) had lower binding affinities for the different muscarinic receptor subtypes than the corresponding quinuclidin-2-ene analogues when examined in the various tissue homogenates. In general, the new compounds showed low subtype selectivity. The structure-affinity relationships are discussed in terms of differences in proton basicity of the azabicyclic nitrogen and differences in geometric, conformational, and/or electronic properties of the compounds. The cortical antimuscarinic potency is also related to the complementarity of the compounds to the putative binding site of the muscarinic m1 receptor.

PubMedSearch : Nilsson_1995_J.Med.Chem_38_473
PubMedID: 7853341

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Citations formats

Nilsson BM, Sundquist S, Johansson G, Nordvall G, Glas G, Nilvebrant L, Hacksell U (1995)
3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships
Journal of Medicinal Chemistry 38 :473

Nilsson BM, Sundquist S, Johansson G, Nordvall G, Glas G, Nilvebrant L, Hacksell U (1995)
Journal of Medicinal Chemistry 38 :473