| Title : New diterpenoid alkaloids from Aconitum heterophyllum Wall: Selective butyrylcholinestrase inhibitors - Nisar_2009_J.Enzyme.Inhib.Med.Chem_24_47 |
| Author(s) : Nisar M , Ahmad M , Wadood N , Lodhi MA , Shaheen F , Choudhary MI |
| Ref : J Enzyme Inhib Med Chem , 24 :47 , 2009 |
|
Abstract :
Two new diterpenoid alkaloids, heterophyllinine-A (1) and heterophyllinine-B (2), along with two known alkaloids dihydroatisine (3) and lycoctonine (4) were isolated from the roots of Aconitum heterophyllum Wall. The structure of (1) and (2), were deduced on the basis of spectral data. Compounds 1-2 inhibited acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) enzymes in a concentration-dependent manner with percent inhibition ranging between 4.24% and 6.94 % and 79.1 % and 82.75 % for AChE and BChE, respectively indicating that compounds 1 and 2 are about thirteen times more specific to BChE than AChE. |
| PubMedSearch : Nisar_2009_J.Enzyme.Inhib.Med.Chem_24_47 |
| PubMedID: 18615279 |
Nisar M, Ahmad M, Wadood N, Lodhi MA, Shaheen F, Choudhary MI (2009)
New diterpenoid alkaloids from Aconitum heterophyllum Wall: Selective butyrylcholinestrase inhibitors
J Enzyme Inhib Med Chem
24 :47
Nisar M, Ahmad M, Wadood N, Lodhi MA, Shaheen F, Choudhary MI (2009)
J Enzyme Inhib Med Chem
24 :47