Nishida_2019_Intern.Med_58_1003

Reference

Title : Cerebellar Cognitive Affective Syndrome Improved by Donepezil - Nishida_2019_Intern.Med_58_1003
Author(s) : Nishida Y , Hizume M , Fumimura Y , Ichikawa T
Ref : Intern Med , 58 :1003 , 2019
Abstract :

Cerebellar damage can cause not only disturbance in motor control but also higher brain dysfunction known as cerebellar cognitive affective syndrome (CCAS). Although CCAS has a high prevalence, the precise mechanism and effective medications are unknown. We herein report a CCAS patient whose symptoms were ameliorated with the cholinesterase inhibitor donepezil. N-isopropyl-p-(123)I-iodoamphetamine-single-photon emission computed tomography showed improvement in hypoperfusion in the contralateral frontal and parieto-temporal lobes. Some projections with cholinergic transmission might form a functional connectivity between the cerebellum and contralateral association cortices, and cholinergic dysfunction is involved in CCAS pathophysiology. Donepezil might be worth considering for some CCAS patients.

PubMedSearch : Nishida_2019_Intern.Med_58_1003
PubMedID: 30568118

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Citations formats

Nishida Y, Hizume M, Fumimura Y, Ichikawa T (2019)
Cerebellar Cognitive Affective Syndrome Improved by Donepezil
Intern Med 58 :1003

Nishida Y, Hizume M, Fumimura Y, Ichikawa T (2019)
Intern Med 58 :1003