| Title : Chemical constituents from the stems of Ephedra intermedia and their alpha-glucosidase and AChE inhibitory effects - Niu_2025_Fitoterapia_182_106433 |
| Author(s) : Niu Y , Liu YL , Cao YG , Zhao YX , Chen X , Lu D , Zhao BX , Zheng XK , Feng WS |
| Ref : Fitoterapia , 182 :106433 , 2025 |
|
Abstract :
Five undescribed glycosides (1-5) and eight known compounds (6-13) were isolated from the stems of Ephedra intermedia. Their chemical structures were determined by analysis of NMR, ECD, and MS data. In addition, The in vitro bioactive assay, alpha-glucosidase and acetylcholinesterase (AChE) inhibitory activities, suggested that compounds 11 and 12 exhibited obvious inhibitory effects on alpha-glucosidase with the IC(50) value of 49.51 +/- 0.97 microM and 47.12 +/- 0.98 microM, respectively, compounds 4 and 5 showed weak inhibitory effects on AChE at the concentration of 100 microM. |
| PubMedSearch : Niu_2025_Fitoterapia_182_106433 |
| PubMedID: 39938660 |
Niu Y, Liu YL, Cao YG, Zhao YX, Chen X, Lu D, Zhao BX, Zheng XK, Feng WS (2025)
Chemical constituents from the stems of Ephedra intermedia and their alpha-glucosidase and AChE inhibitory effects
Fitoterapia
182 :106433
Niu Y, Liu YL, Cao YG, Zhao YX, Chen X, Lu D, Zhao BX, Zheng XK, Feng WS (2025)
Fitoterapia
182 :106433