Njan_2020_Heliyon_6_e03514

Reference

Title : Subchronic exposure to Kafura\; its neurotoxic potentials in young adult female Wistar rats - Njan_2020_Heliyon_6_e03514
Author(s) : Njan AA , Ologe MO , Olorundare OE , Afolabi SO , Ejimkonye BC , Olaoye SO , Fatigun CO , Akinola O , Soje A , Erdogan ON , Asogwa N , Iwalewa OE
Ref : Heliyon , 6 :e03514 , 2020
Abstract :

Background: Kafura pelebe (camphor) {C10H16O} is a chemical substance used mostly amongst the Yoruba ethnic group in Western Nigeria to treat infantile colic during early childhood. This study assess the neurotoxic potentials of Kafura following sub-chronic exposure in female albino Wistar rats. Methods: Twenty-eight female rats (mean weight of 130 g) were randomly selected and assigned into four (4) groups. Control, received 1ml coconut oil while the treatment groups received 79, 158 and 237. mg/kg b.wt (d ose p.o) of Kafura for the period of 14 days. On day fifteen, animals were dissected and the brain organ excised for the homogenate and histopathologic assay, blood samples were also collected for haematological analysis. Morris Water Maze experiment for reference memory was also carried out to ascertain effect of Kafura in the Central Nervous system (CNS). Results: A trend toward decreased body-weight gain and increase brain weight was observed in Kafura-treated rats but was statistically not significant, compared to control. The biochemical assessment of the antioxidant status of brains of Kafura-treated rats showed significant (p

PubMedSearch : Njan_2020_Heliyon_6_e03514
PubMedID: 32190756

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Citations formats

Njan AA, Ologe MO, Olorundare OE, Afolabi SO, Ejimkonye BC, Olaoye SO, Fatigun CO, Akinola O, Soje A, Erdogan ON, Asogwa N, Iwalewa OE (2020)
Subchronic exposure to Kafura\; its neurotoxic potentials in young adult female Wistar rats
Heliyon 6 :e03514

Njan AA, Ologe MO, Olorundare OE, Afolabi SO, Ejimkonye BC, Olaoye SO, Fatigun CO, Akinola O, Soje A, Erdogan ON, Asogwa N, Iwalewa OE (2020)
Heliyon 6 :e03514