| Title : Design of a 15N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State - Nonaka_2017_Sci.Rep_7_40104 |
| Author(s) : Nonaka H , Hirano M , Imakura Y , Takakusagi Y , Ichikawa K , Sando S |
| Ref : Sci Rep , 7 :40104 , 2017 |
|
Abstract :
Nuclear hyperpolarization is a phenomenon that can be used to improve the sensitivity of magnetic resonance molecular sensors. However, such sensors typically suffer from short hyperpolarization lifetime. Herein we report that [15N, D14]trimethylphenylammonium (TMPA) has a remarkably long spin-lattice relaxation time (1128 s, 14.1 T, 30 degrees C, D2O) on its 15N nuclei and achieves a long retention of the hyperpolarized state. [15N, D14]TMPA-based hyperpolarized sensor for carboxylesterase allowed the highly sensitive analysis of enzymatic reaction by 15N NMR for over 40 min in phophate-buffered saline (H2O, pH 7.4, 37 degrees C). |
| PubMedSearch : Nonaka_2017_Sci.Rep_7_40104 |
| PubMedID: 28067292 |
Nonaka H, Hirano M, Imakura Y, Takakusagi Y, Ichikawa K, Sando S (2017)
Design of a 15N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State
Sci Rep
7 :40104
Nonaka H, Hirano M, Imakura Y, Takakusagi Y, Ichikawa K, Sando S (2017)
Sci Rep
7 :40104