| Title : Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains - Nordberg_1988_Neurosci.Lett_86_317 |
| Author(s) : Nordberg A , Adem A , Hardy J , Winblad B |
| Ref : Neuroscience Letters , 86 :317 , 1988 |
|
Abstract :
Competition experiments using (-)-[3H]nicotine and unlabelled nicotine revealed both high and low affinity nicotinic binding sites in temporal cortex of control and Alzheimer (AD/SDAT) brains. A significant reduction in the proportion of high affinity nicotinic binding sites (-20%) and a parallel increase in the proportion of low affinity nicotinic binding sites was obtained in AD/SDAT brain cortex compared to control brain. Moreover, a marked decrease was observed in the affinity of the low affinity nicotinic binding sites in AD/SDAT. |
| PubMedSearch : Nordberg_1988_Neurosci.Lett_86_317 |
| PubMedID: 3380323 |
Nordberg A, Adem A, Hardy J, Winblad B (1988)
Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains
Neuroscience Letters
86 :317
Nordberg A, Adem A, Hardy J, Winblad B (1988)
Neuroscience Letters
86 :317