Nos_2019_Chemosphere_238_124592

Reference

Title : Tetrabromobisphenol A inhibits carboxylesterase activity of marine organisms from different trophic levels - Nos_2019_Chemosphere_238_124592
Author(s) : Nos D , Navarro J , Saiz E , Sanchez-Hernandez JC , Sole M
Ref : Chemosphere , 238 :124592 , 2019
Abstract :

Tetrabromobisphenol A (TBBPA), a brominated flame retardant used in synthetic polymers and electronics, is present in the aquatic environment and recent evidence suggests it can be potentially biomagnified in the marine ecosystem. However, the toxicity of TBBPA in the marine biota has not been investigated in detail. In this study we aimed to understand the role of carboxylesterases (CEs) in xenobiotic metabolism under the exposure of marine organisms to a chemical of environmental concern, TBBPA. Specifically, we tested for in vitro inhibition of CE activity in a range of marine organisms covering different ecological niches, from species from low (mussels and copepods), medium (sardines and anchovies) and high trophic levels (tuna). The results revealed that the highest inhibition of CE activity to 100muM TBBPA was recorded in mussels (66.5% inhibition) and tunids (36.3-76.4%), whereas copepods and small pelagic fish showed comparatively lower effects (respectively, 30% and 36.5-55.6%). Our results suggest that CE-mediated detoxification and physiological processes could be compromised in TBBPA-exposed organisms and could ultimately affect humans as many of them are market species.

PubMedSearch : Nos_2019_Chemosphere_238_124592
PubMedID: 31442778

Related information

Citations formats

Nos D, Navarro J, Saiz E, Sanchez-Hernandez JC, Sole M (2019)
Tetrabromobisphenol A inhibits carboxylesterase activity of marine organisms from different trophic levels
Chemosphere 238 :124592

Nos D, Navarro J, Saiz E, Sanchez-Hernandez JC, Sole M (2019)
Chemosphere 238 :124592