| Title : (+)-Chenabinol (Revised NMR Data) and Two New Alkaloids from Berberis vulgaris and their Biological Activity - Novak_2015_Nat.Prod.Commun_10_1695 |
| Author(s) : Novak Z , Host'alkova A , Opletal L , Novakova L , Hrabinova M , Kunes J , Cahlikova L |
| Ref : Nat Prod Commun , 10 :1695 , 2015 |
|
Abstract :
A known alkaloid (+)-chenabinol (1) and two new secobisbenzylisoquinoline alkaloids were isolated by standard chromatographic methods from the root bark of Berberis vulgaris L. The structures of the new alkaloids, named berkristine (2) and verfilline (3), were established by spectroscopic (including 2D NMR), and HRMS (ESI) methods. The alkaloids were tested for their inhibition activity of human cholinesterases and prolyl oligopeptidase. Compound 1 inhibited human butyrylcholinesterase with an IC50 value of 44.8 +/- 5.4 muM. |
| PubMedSearch : Novak_2015_Nat.Prod.Commun_10_1695 |
| PubMedID: 26669104 |
Novak Z, Host'alkova A, Opletal L, Novakova L, Hrabinova M, Kunes J, Cahlikova L (2015)
(+)-Chenabinol (Revised NMR Data) and Two New Alkaloids from Berberis vulgaris and their Biological Activity
Nat Prod Commun
10 :1695
Novak Z, Host'alkova A, Opletal L, Novakova L, Hrabinova M, Kunes J, Cahlikova L (2015)
Nat Prod Commun
10 :1695