| Title : Effects of phenylhydrazine or recombinant human erythropoietin on deformability and activity of dehydrogenase glucose-6-phosphate and acetylcholinesterase in Wistar rats blood enriched in reticulocytes - Nowak_2003_Folia.Biol.(Krakow)_51_195 |
| Author(s) : Nowak E , Wyrwicz G , Dabrowski Z , Smolenski O , Spodaryk K |
| Ref : Folia Biol (Krakow) , 51 :195 , 2003 |
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Abstract :
Deformability and activity of the enzymes: acetylcholinesterase (AChE) and dehydrogenase glucose-6-phosphate (G-6-PD), were assayed for RBC enriched in immature reticulocytes. Reticulocytosis was evoked by administration of two different drugs: recombinant human erythropoietin (rHuEPO) and phenylhydrazine (PHZ) to two groups of Wistar rats. After treatment with the former compound, a group of animals exhibited 17.33% reticulocytes in blood whereas a group of rats treated with the latter drug reached 57.66% of these cells in blood. A marked decrease in RBC deformability was found in both groups of animals. AChE did not significantly change activity neither in PHZ-treated nor in rHuEPO-treated rats, whereas G-6-PD activity was significantly decreased in the PHZ-treated group. |
| PubMedSearch : Nowak_2003_Folia.Biol.(Krakow)_51_195 |
| PubMedID: 15303374 |
Nowak E, Wyrwicz G, Dabrowski Z, Smolenski O, Spodaryk K (2003)
Effects of phenylhydrazine or recombinant human erythropoietin on deformability and activity of dehydrogenase glucose-6-phosphate and acetylcholinesterase in Wistar rats blood enriched in reticulocytes
Folia Biol (Krakow)
51 :195
Nowak E, Wyrwicz G, Dabrowski Z, Smolenski O, Spodaryk K (2003)
Folia Biol (Krakow)
51 :195