Nuutinen_2007_Neuroreport_18_121

Reference

Title : Differential effects of acute and chronic nicotine on Elk-1 in rat hippocampus - Nuutinen_2007_Neuroreport_18_121
Author(s) : Nuutinen S , Barik J , Jones IW , Wonnacott S
Ref : Neuroreport , 18 :121 , 2007
Abstract :

Transcriptional regulation is central to the long-term effects of drugs of abuse. Activation of the extracellular signal-regulated kinase (ERK1/2) pathway underlies plasticity changes that accompany drug use. One target of ERK1/2 activation is the Ets-like transcription factor Elk-1. We show here that nicotine modulates Elk-1 in the rat hippocampus in a spatially and temporally specific manner. In-vitro nicotine (1 muM) activated Elk-1 in hippocampal slices. In-vivo acute nicotine (0.4 mg/kg) activated Elk-1 in the CA1 area but not in the dentate gyrus. Chronic nicotine for 14 days changed the level of total Elk-1 but not its phosphorylation state. Thus, Elk-1 regulation of transcriptional events may contribute to nicotine-induced changes in the hippocampus.

PubMedSearch : Nuutinen_2007_Neuroreport_18_121
PubMedID: 17301675

Related information

Citations formats

Nuutinen S, Barik J, Jones IW, Wonnacott S (2007)
Differential effects of acute and chronic nicotine on Elk-1 in rat hippocampus
Neuroreport 18 :121

Nuutinen S, Barik J, Jones IW, Wonnacott S (2007)
Neuroreport 18 :121