Title : Identification of novel single nucleotide polymorphisms (SNPs) of the lipoprotein lipase (LPL) gene associated with fatty acid composition in Korean cattle - Oh_2013_Mol.Biol.Rep_40_3155 |
Author(s) : Oh D , La B , Lee Y , Byun Y , Lee J , Yeo G , Yeo J |
Ref : Mol Biol Rep , 40 :3155 , 2013 |
Abstract :
The lipoprotein lipase (LPL) gene can be considered a functional candidate gene that regulates fatty acid composition. In this study, genetic associations between fatty acid composition and exonic single nucleotide polymorphisms (SNPs) in the LPL gene were examined using 612 Korean cattle. We investigated the relationship between unsaturated fatty acids and five novel SNPs (c.322G>A, c.329A>T, c.527T>G, c.988C>T and c.1591G>A), and confirmed that three polymorphic SNPs (c.322G>A, c.329A>T and c.1591G>A) were associated with fatty acid composition. Korean cattle with an AA genotype of c.322G>A, c.329A>T, and GA genotype of c.1591G>A had higher levels of monounsaturated fatty acids and carcass traits (P < 0.05). Our findings confirmed that three novel SNPs we identified in the LPL gene can affect fatty acid composition and carcass traits. Therefore, selection for AA and GA genotypes should be recommended to genetically improve beef quality and flavor. |
PubMedSearch : Oh_2013_Mol.Biol.Rep_40_3155 |
PubMedID: 23271120 |
Gene_locus related to this paper: bovin-lipli |
Gene_locus | bovin-lipli |
Oh D, La B, Lee Y, Byun Y, Lee J, Yeo G, Yeo J (2013)
Identification of novel single nucleotide polymorphisms (SNPs) of the lipoprotein lipase (LPL) gene associated with fatty acid composition in Korean cattle
Mol Biol Rep
40 :3155
Oh D, La B, Lee Y, Byun Y, Lee J, Yeo G, Yeo J (2013)
Mol Biol Rep
40 :3155