| Title : Bis-neonicotinoid insecticides: Observed and predicted binding interactions with the nicotinic receptor - Ohno_2009_Bioorg.Med.Chem.Lett_19_3449 |
| Author(s) : Ohno I , Tomizawa M , Durkin KA , Casida JE , Kagabu S |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :3449 , 2009 |
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Abstract :
The bis-pharmacophore approach applied to neonicotinoid insecticides reveals high binding affinity for heptamethylene bis-N(3),N(3')-imidacloprid fitting a nicotinic acetylcholine receptor model wherein the chloropyridine moieties contact loops E and F and the alkylene linker bridges these two distant domains. |
| PubMedSearch : Ohno_2009_Bioorg.Med.Chem.Lett_19_3449 |
| PubMedID: 19473841 |
Ohno I, Tomizawa M, Durkin KA, Casida JE, Kagabu S (2009)
Bis-neonicotinoid insecticides: Observed and predicted binding interactions with the nicotinic receptor
Bioorganic & Medicinal Chemistry Lett
19 :3449
Ohno I, Tomizawa M, Durkin KA, Casida JE, Kagabu S (2009)
Bioorganic & Medicinal Chemistry Lett
19 :3449