Okada_2016_Neurochem.Int_97_109

Reference

Title : Brain effects of manganese exposure in mice pups during prenatal and breastfeeding periods - Okada_2016_Neurochem.Int_97_109
Author(s) : Okada MA , Neto FF , Noso CH , Voigt CL , Campos SX , Alberto de Oliveira Ribeiro C
Ref : Neurochem Int , 97 :109 , 2016
Abstract :

Manganese (Mn) is a trace element essential for brain development and functioning of the central nervous system. However, there is a lack of information concerning the neurotoxicity of Mn under realistic doses in early stages of development, though excess of Mn results in a progressive disorder of the nervous system called manganism. In the current study, adult mice were exposed to three doses of Mn for 60 days through daily gavages, while mice pups were exposed to the same Mn doses during developmental period (gestational and breast-feeding). From the latter group of mice, a group was exposed for more 60 days to the same Mn doses. Chemical analysis revealed a dose-dependent bioaccumulation of Mn in mice's brain. Biochemical parameters revealed that (1) Mn affects non-protein thiol levels, glutathione S-tranferase and acetylcholinesterase activities, as well as the levels of oxidized lipids and proteins in mice brain, though lipids and proteins alterations were found only after exposure to high and unrealistic doses; (2) Realistic doses of Mn affects the activity of brain AChE and finally; (3) Pups' brain were affected by Mn even whether only the parental females had been previously exposed. The current study shows evidences of chemical stress in mice exposed to Mn during the early period of development and an efficient mechanism of Mn elimination under higher doses. These findings open new lines of investigation regarding manganese toxicity in vertebrates mainly in the early stages of development.

PubMedSearch : Okada_2016_Neurochem.Int_97_109
PubMedID: 26972613

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Citations formats

Okada MA, Neto FF, Noso CH, Voigt CL, Campos SX, Alberto de Oliveira Ribeiro C (2016)
Brain effects of manganese exposure in mice pups during prenatal and breastfeeding periods
Neurochem Int 97 :109

Okada MA, Neto FF, Noso CH, Voigt CL, Campos SX, Alberto de Oliveira Ribeiro C (2016)
Neurochem Int 97 :109