Olivera_2005_Chem.Biol.Interact_157-158_410

We studied acetylcholinesterase (AChE) effects on glutamate receptors (GluR) in rat brain sections, synaptosomal membranes and cultured hippocampal neurones. A selective potentiation of AMPA receptors (AMPAR) binding in AMPAR-enriched layers undergoing synaptogenesis plus an increased surface expression of synaptic clusters of GluR1, GluR2, and SV2a was found. Thus, the AMPAR synaptic recruitment induced by AChE, could be a molecular mechanism underlying its non-classical synaptogenic actions.