| Title : Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis - Ongaro_2025_Science_387_329 |
| Author(s) : Ongaro L , Zhou X , Wang Y , Schultz H , Zhou Z , Buddle ERS , Brle E , Lin YF , Schang G , Hagg A , Castonguay R , Liu Y , Su GH , Seidah NG , Ray KC , Karp SJ , Boehm U , Ruf-Zamojski F , Sealfon SC , Walton KL , Lee SJ , Bernard DJ |
| Ref : Science , 387 :329 , 2025 |
|
Abstract :
Myostatin is a paracrine myokine that regulates muscle mass in a variety of species, including humans. In this work, we report a functional role for myostatin as an endocrine hormone that directly promotes pituitary follicle-stimulating hormone (FSH) synthesis and thereby ovarian function in mice. Previously, this FSH-stimulating role was attributed to other members of the transforming growth factor-beta family, the activins. Our results both challenge activin's eponymous role in FSH synthesis and establish an unexpected endocrine axis between skeletal muscle and the pituitary gland. Our data also suggest that efforts to antagonize myostatin to increase muscle mass may have unintended consequences on fertility. |
| PubMedSearch : Ongaro_2025_Science_387_329 |
| PubMedID: 39818879 |
Ongaro L, Zhou X, Wang Y, Schultz H, Zhou Z, Buddle ERS, Brle E, Lin YF, Schang G, Hagg A, Castonguay R, Liu Y, Su GH, Seidah NG, Ray KC, Karp SJ, Boehm U, Ruf-Zamojski F, Sealfon SC, Walton KL, Lee SJ, Bernard DJ (2025)
Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis
Science
387 :329
Ongaro L, Zhou X, Wang Y, Schultz H, Zhou Z, Buddle ERS, Brle E, Lin YF, Schang G, Hagg A, Castonguay R, Liu Y, Su GH, Seidah NG, Ray KC, Karp SJ, Boehm U, Ruf-Zamojski F, Sealfon SC, Walton KL, Lee SJ, Bernard DJ (2025)
Science
387 :329