| Title : The Drosophila Mutant tetanic Interacts with a Gene Complex Including the Structural Locus of K+ Channels and Shows Altered Dephosphorylation and Learning - Orgad_1989_Eur.J.Neurosci_1_367 |
| Author(s) : Orgad S , Llamazares S , Dudai Y , Ferrus A |
| Ref : European Journal of Neuroscience , 1 :367 , 1989 |
|
Abstract :
The tetanic (tta; X.-52.6) mutation has been isolated on the basis of its sensitivity to extradoses of the normal Shaker gene complex (ShC) where the K+ channel la is encoded. The mutant shows up to threefold elevation of the membrane bound protein phosphatase type 1 (PP1) activity in body extracts, probably due to reduced levels of the PP1 specific inhibitor 2 (I-2). By contrast, PP1 activity in the head is only half of the normal value. In addition, tta fails to perform normally in a negative reinforcement olfactory paradigm. The functional relationships between phosphorylation, K+ currents, phosphatase activity and modulation of synaptic activity during learning and memory are discussed in the light of their possible genetic links. |
| PubMedSearch : Orgad_1989_Eur.J.Neurosci_1_367 |
| PubMedID: 12106145 |
Orgad S, Llamazares S, Dudai Y, Ferrus A (1989)
The Drosophila Mutant tetanic Interacts with a Gene Complex Including the Structural Locus of K+ Channels and Shows Altered Dephosphorylation and Learning
European Journal of Neuroscience
1 :367
Orgad S, Llamazares S, Dudai Y, Ferrus A (1989)
European Journal of Neuroscience
1 :367