| Title : Synthesis of 3-octadecanoxypropyl 6-deoxy-6-sulfo-alpha-D-glucopyranoside (ODSG) as a lipase-resistant SQAP derivative - Oshige_2021_Bioorg.Med.Chem.Lett__128391 |
| Author(s) : Oshige M , Kano K , Shinada S , Kawaguchi A , Uchida T , Ishii N , Horiuchi H , Sugawara F , Sakaguchi K , Matsuo I , Katsura S |
| Ref : Bioorganic & Medicinal Chemistry Lett , :128391 , 2021 |
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Abstract :
Sulfoquynovosylacyl propanediol (SQAP; 1) has been developed as a radiosensitizer (anti-cancer agent) for solid tumors, but it was easily cleaved in vivo and had a problem of short residence time. We synthesized a novel compound of a SQAP derivative (3-octadecanoxypropyl 6-deoxy-6-sulfo-alpha-D-glucopyranoside: ODSG; 2) to solve these problems not easily cleaved by lipase. ODSG (2) cytotoxicity was investigated in vitro, resulting in low toxicity like SQAP (1). |
| PubMedSearch : Oshige_2021_Bioorg.Med.Chem.Lett__128391 |
| PubMedID: 34601028 |
Oshige M, Kano K, Shinada S, Kawaguchi A, Uchida T, Ishii N, Horiuchi H, Sugawara F, Sakaguchi K, Matsuo I, Katsura S (2021)
Synthesis of 3-octadecanoxypropyl 6-deoxy-6-sulfo-alpha-D-glucopyranoside (ODSG) as a lipase-resistant SQAP derivative
Bioorganic & Medicinal Chemistry Lett
:128391
Oshige M, Kano K, Shinada S, Kawaguchi A, Uchida T, Ishii N, Horiuchi H, Sugawara F, Sakaguchi K, Matsuo I, Katsura S (2021)
Bioorganic & Medicinal Chemistry Lett
:128391