Title : Dose-response relationship for mivacurium in patients with phenotypically abnormal plasma cholinesterase activity [see comments] - Ostergaard_1995_Acta.Anaesthesiol.Scand_39_1016 |
Author(s) : Ostergaard D , Jensen FS , Skovgaard LT , Viby-Mogensen J |
Ref : Acta Anaesthesiologica Scandinavica , 39 :1016 , 1995 |
Abstract :
During thiopentone-fentanyl-nitrous oxide anaesthesia and using a cumulative design, we studied the dose-response relationship of mivacurium in 8 patients: 7 patients phenotypically homozygous for the atypical plasma cholinesterase gene and 1 patient homozygous for the silent gene. The estimated mean ED50 and ED95 were 15 and 20 micrograms.kg.bw-1 in patients homozygous for the atypical gene, and 13 and 16 micrograms.kg.bw-1 in the patient homozygous for the silent gene, respectively. The results indicate that mivacurium is 4-5 times more potent in patients homozygous for the atypical or the silent gene than in patients with normal plasma cholinesterase activity and phenotype. |
PubMedSearch : Ostergaard_1995_Acta.Anaesthesiol.Scand_39_1016 |
PubMedID: 8607300 |
Ostergaard D, Jensen FS, Skovgaard LT, Viby-Mogensen J (1995)
Dose-response relationship for mivacurium in patients with phenotypically abnormal plasma cholinesterase activity [see comments]
Acta Anaesthesiologica Scandinavica
39 :1016
Ostergaard D, Jensen FS, Skovgaard LT, Viby-Mogensen J (1995)
Acta Anaesthesiologica Scandinavica
39 :1016